Blar i forfatter "Zykov, Ilya Nikolaevich"
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Efficacy of mecillinam against clinical multidrug-resistant Escherichia coli in a murine urinary tract infection model
Zykov, Ilya Nikolaevich; Frimodt-Møller, Niels; Småbrekke, Lars; Sundsfjord, Arnfinn; Samuelsen, Ørjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-23)Pivmecillinam, a pro-drug of mecillinam, has been used extensively in Scandinavia for the treatment of acute lower urinary tract infections (UTIs) caused by Enterobacterales. It is still an attractive first-line drug for the empirical treatment of UTIs owing to the low prevalence of resistance as well as its favourable impact on the intestinal microbiota as a pro-drug and good in vitro efficacy ... -
Old antibiotics as alternative treatment options for urinary tract infections caused by ESBL-, AmpC- and carbapenemase-producing Escherichia coli
Zykov, Ilya Nikolaevich (Doctoral thesis; Doktorgradsavhandling, 2020-05-25)Multidrug-resistant (MDR) bacteria, including Escherichia coli, producing extended-spectrum β-lactamase (ESBL), AmpC or carbapenemases, are acknowledged among the most significant global health threats. Growing rates of MDR E.coli can lead to an increase in the use of reserve antimicrobials. Re-introducing “old antimicrobials” could offer a timely solution. This work aimed at evaluating the role of ... -
Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model
Zykov, Ilya Nikolaevich; Samuelsen, Ørjan; Jakobsen, Lotte; Småbrekke, Lars; Andersson, Dan I.; Sundsfjord, Arnfinn; Frimodt-Møller, Niels (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-25)Fosfomycin has become an attractive treatment alternative for urinary tract infections (UTIs) due to increasing multidrug resistance (MDR) in <i>Escherichia coli</i>. In this study, we evaluated the pharmacokinetic (PK) and pharmacodynamic (PD) indices of fosfomycin and its <i>in vivo</i> activity in an experimental murine model of ascending UTI. Subcutaneous administration of fosfomycin showed that ...